Chapter 18. Mitochondrial Dysfunction and Oxidative Stress

  1. Lakshmi N. Yatham4 and
  2. Mario Maj5
  1. Tadafumi Kato1,
  2. Flavio Kapczinski2 and
  3. Michael Berk3

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch18

Bipolar Disorder

Bipolar Disorder

How to Cite

Kato, T., Kapczinski, F. and Berk, M. (2010) Mitochondrial Dysfunction and Oxidative Stress, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch18

Editor Information

  1. 4

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 5

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Hirosawa 2-1, Wako, Saitama, 350-0198, Japan

  2. 2

    ISBD Hospital de Clinicas, UFRGS Brazil Porto Alegre, RS, Brazil

  3. 3

    Barwon Health and the Geelong Clinic, University of Melbourne, Kitchener House, Ryrie Street, Geelong, Victoria 3220, Australia

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • mitochondrial dysfunction and oxidative stress;
  • biological aspects of bipolar disorder - as genetics, brain imaging, neurotransmitters, neuroendocrinology, circadian rhythms and pharmacology;
  • cellular vulnerability in bipolar disorder;
  • phosphorous magnetic resonance spectroscopy - in bipolar disorder;
  • phosphorus-31 magnetic resonance spectroscopy (31P-MRS);
  • missense mutation of adenine nucleotide translocator 1 (ANT1) (L98P);
  • role of mitochondrial DNA deletion - in bipolar disorder;
  • gene expression analysis;
  • consequence of mitochondrial dysfunction;
  • mitochondrial dysfunction - and oxidative stress


This chapter contains sections titled:

  • Introduction

  • Cellular vulnerability in bipolar disorder

  • Phosphorous magnetic resonance spectroscopy in bipolar disorder

  • Role of mitochondrial DNA deletion in bipolar disorder

  • Gene expression analysis

  • Genetics

  • Animal models

  • Consequence of mitochondrial dysfunction

  • Calcium signalling

  • Progressive cell loss

  • Oxidative stress and mitochondrial dysfunction: a vicious cycle propelled by dopaminergic hyperactivity?

  • Oxidative stress markers in bipolar disorder

  • Treatment studies

  • Effects of known treatment on oxidative systems

  • Glutathione precursors

  • Conclusion

  • References