Chapter 19. Neuroendocrinology of Bipolar Illness

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Timothy Dinan1 and
  2. Michael Bauer2

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch19

Bipolar Disorder

Bipolar Disorder

How to Cite

Dinan, T. and Bauer, M. (2010) Neuroendocrinology of Bipolar Illness, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch19

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Department of Psychiatry, Cork University Hospital, Wilton, Cork, Ireland

  2. 2

    Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Technische Universität, Dresden, Fetscherstraße 74, D-01307 Dresden, Germany

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • bipolar illness neuroendocrinology;
  • bipolar disorder, enigmatic - from pathophysiological perspective;
  • hypothalamic-pituitary-adrenal axis (HPA) and hypothalamic-pituitary-thyroid axis (HPT) function in bipolar illness;
  • parvicellar neurones co-express vasopressin (AVP) - role in sustaining HPA activation;
  • basal HPA activity in bipolar disorder;
  • sympathoadrenal medullary system (SAM), and components of fight or flight response with release of catecholamines;
  • CRH receptors, CRHR1 and CRHR2 - Wasserman et al. and single nucleotide polymorphisms (SNPs) analysis in CRH1 gene;
  • thyroid hormone metabolism - critical role in human brain development;
  • thyroid hormones in mood disorder treatment;
  • thyroid hormones, multitude of effects on central nervous system


This chapter contains sections titled:

  • HPA regulation

  • Basal HPA activity in bipolar disorder

  • Dexamethasone suppression test (DST)

  • Dexamethasone/CRH test

  • DEX/vasopressin test

  • CRH receptor studies

  • Corticoid receptors

  • Thyroid hormones

  • Thyroid status in patients with affective disorders

  • Rapid cycling bipolar disorder

  • Conclusions and future directions

  • References