Chapter 20. Circadian Rhythms and Sleep in Bipolar Disorder

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Greg Murray1 and
  2. Allison Harvey2

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch20

Bipolar Disorder

Bipolar Disorder

How to Cite

Murray, G. and Harvey, A. (2010) Circadian Rhythms and Sleep in Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch20

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Faculty of Life and Social Sciences, Swinburne University of Technology, PO Box 218 John Street, Hawthorn 3122, Australia

  2. 2

    Psychology Department, Sleep and Psychological Disorders, Lab, University of California, 3210 Tolman Hall, Berkeley, CA 94720-1650, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • circadian rhythms and sleep in bipolar disorder;
  • circadian rhythm hypotheses - in bipolar disorder (BD) explanation;
  • endogenous period in SCN, close to, not equal to 24-hour;
  • circadian rhythms and sleep - circadian system;
  • biological rhythms and BD association - causal inferences considered;
  • rapid eye movement (REM) and non-rapid eye movement (NREM);
  • arousal system, curtailed to produce sleep - involving ventrolateral preoptic nucleus (VLPO);
  • circadian and sleep processes - bidirectional interaction between C and S, predicting propensity, timing and internal structure of sleep;
  • mechanisms underpinning biological rhythm involvement in BD;
  • biology and psychosocial factor interaction - not ignored in biological rhythm approach to BD


This chapter contains sections titled:

  • Introduction and overview

  • Circadian rhythms and sleep

  • Sleep, circadian function and affect

  • Sleep, circadian function and mood symptoms in BD

  • Mechanisms underpinning biological rhythm involvement in BD

  • Psychosocial interventions targeting biological rhythms in BD

  • Summary and conclusions

  • References