Chapter 22. Acute Mania

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Paul E. Keck Jr.,
  2. Susan L. McElroy and
  3. John M. Hawkins Associate Professor

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch22

Bipolar Disorder

Bipolar Disorder

How to Cite

Keck, P. E., McElroy, S. L. and Hawkins, J. M. (2010) Acute Mania, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch22

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. Lindner Center of HOPE; Craig & Frances Lindner; Department of Psychiatry, University of Cincinnati College of Medicine, 4075, Old Western Row Road, Mason, OH 45040, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • acute mania;
  • manic and mixed episodes, course of bipolar disorder - and serious acute psychiatric syndromes;
  • pharmacotherapy, cornerstone of treatment - for bipolar manic and mixed episode;
  • Divalproex, commonly studied formulation of valproic acid - in patients with acute bipolar mania;
  • oxcarbazepine, intriguing alternative to carbamazepine;
  • first-generation (typical) antipsychotics;
  • first-generation agents, and rapid acute efficacy - treating psychotic and manic symptoms;
  • second-generation (atypical) antipsychotics;
  • electroconvulsive therapy (ECT), important nonpharmacological treatment option for patients;
  • new potential antimanic agents - paloperidone and asenapine, superior to placebo


This chapter contains sections titled:

  • Introduction

  • Lithium

  • Valproic acid

  • Carbamazepine

  • First-generation (typical) antipsychotics

  • Second-generation (atypical) antipsychotics

  • Electroconvulsive therapy

  • New potential antimanic agents

  • Agents without demonstrated antimanic efficacy

  • Clinical recommendations

  • Summary

  • References