Chapter 23. Pharmacological Treatment of Bipolar Depression

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Allan H. Young1 and
  2. Charles B. Nemeroff2

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch23

Bipolar Disorder

Bipolar Disorder

How to Cite

Young, A. H. and Nemeroff, C. B. (2010) Pharmacological Treatment of Bipolar Depression, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch23

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Institute of Mental Health, Department of Psychiatry, University of British Columbia, Suite 430, 5950 University Blvd., Vancouver, BC V6T 1Z3, Canada

  2. 2

    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami FL, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • pharmacological treatment of bipolar depression;
  • degree of disability - associated with bipolar depression episodes;
  • diagnostic accuracy, intensive scrutiny for presence of manic/hypomanic, psychotic or reverse vegetative symptoms in patients;
  • treatments for management of bipolar I depression;
  • adjunctive lamotrigine, as treatment for bipolar I depression - investigated in Systematic Treatment Enhancement Programme for Bipolar Disorder (STEP-BD);
  • acute efficacy of quetiapine monotherapy - in patients with bipolar I or bipolar II depression;
  • olanzapine and olanzapine/fluoxetine combination - efficacy of olanzapine/fluoxetine combination (OFC);
  • sertraline, bupropion and venlafaxine efficacy - adjunctive treatment to mood-stabilizers;
  • monamine oxidase inhibitors (MAOIs);
  • lamotrigine use, as maintenance treatment - in rapid-cycling bipolar disorder


This chapter contains sections titled:

  • Introduction

  • Treatments for the management of bipolar I depression

  • Pharmacological treatment of bipolar II depression

  • Conclusions

  • Financial disclosures

  • References