Chapter 24. Practical Pharmacological Maintenance Treatment of Bipolar Disorder

  1. Lakshmi N. Yatham2 and
  2. Mario Maj3
  1. Alan C. Swann

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch24

Bipolar Disorder

Bipolar Disorder

How to Cite

Swann, A. C. (2010) Practical Pharmacological Maintenance Treatment of Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch24

Editor Information

  1. 2

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 3

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, 1300 Moursund Street, Houston, TX 77037, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • practical pharmacological maintenance treatment - of bipolar disorder;
  • bipolar disorder - no curative treatments or effective measures for primary prevention;
  • substance-use disorders, worsening course of bipolar disorder - causing serious impairment in their own right;
  • metrics for evaluating and comparing treatments;
  • long-term treatment in bipolar disorder - transition between acute episode and long-term treatment;
  • transition to maintenance - pharmacological management;
  • need to treat residual symptoms;
  • transition to maintenance - complete when s/he is able to handle living and work situation before the episode;
  • Electroconvulsive treatment (ECT) - in acute treatment of bipolar disorder when conventional treatment is not effective or usable;
  • treatment of substance abuse/dependence - in subjects with bipolar disorder


This chapter contains sections titled:

  • Introduction

  • Goals of long-term treatment

  • Adherence to and participation in treatment

  • Nature of evidence: relationship to the goals of treatment

  • Transition to maintenance treatment

  • Maintenance treatment: evidence from controlled trials

  • Treatments for severe illness without evidence from randomized clinical trials

  • Treatment targets other than affective episodes

  • Using major treatments

  • Summary: practical maintenance pharmacological treatment

  • References