Chapter 27. Management of Comorbidity in Bipolar Disorder

  1. Lakshmi N. Yatham4 and
  2. Mario Maj5
  1. Ihsan M. Salloum1,
  2. Luca Pani2 and
  3. Tiffany Cooke3

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch27

Bipolar Disorder

Bipolar Disorder

How to Cite

Salloum, I. M., Pani, L. and Cooke, T. (2010) Management of Comorbidity in Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch27

Editor Information

  1. 4

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 5

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Department of Psychiatry, University of Miami Miller, School of Medicine, 1120 NW 14th Street, Rm 1450, Miami, FL 33136, USA

  2. 2

    Istituto Tecnologie Biomediche, Consiglio Nazionale delle Ricerche, Sede di Cagliari-Pula and PharmaNess Scarl, Edificio 5 - Parco Scientifico e Tecnologico della Sardegna - 09010 Pula (Cagliari), Italy

  3. 3

    Emory University, Rollins School of Public Health, 1518 Clifton Road Northeast Atlanta, GA 30329, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • comorbidity management in bipolar disorder;
  • comorbidity, in general medicine - impact of associated clinical entities;
  • chronic course of bipolar disorder - need for polypharmacy in treatment;
  • faces of comorbidity in bipolar disorder;
  • Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) sample;
  • substance use disorder, other major psychiatric comorbidity with bipolar disorder;
  • National Epidemiologic Survey on Alcohol and Related Conditions (NESARC);
  • integrated care provision - integration efforts occurring at multiple levels;
  • role of systematic screening;
  • treatment guidance - for comorbid anxiety disorders


This chapter contains sections titled:

  • Introduction

  • Faces of comorbidity in bipolar disorder

  • Management issues

  • Diagnostic considerations

  • The role of systematic screening

  • General treatment considerations

  • Treatment phases

  • Pharmacotherapy

  • Issues related to specific medications

  • Conclusion

  • References