Chapter 30. Novel Therapeutic Strategies for Bipolar Disorder

  1. Lakshmi N. Yatham4 and
  2. Mario Maj5
  1. Rodrigo Machado-Vieira1,
  2. Husseini K. Manji2 and
  3. Carlos A. Zarate Jr3

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch30

Bipolar Disorder

Bipolar Disorder

How to Cite

Machado-Vieira, R., Manji, H. K. and Zarate, C. A. (2010) Novel Therapeutic Strategies for Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch30

Editor Information

  1. 4

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 5

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Experimental Therapeutics, Mood and Anxiety Disorders, Research Program, NIMH-NIH, Bldg 15K, 15 North Drive, MSC 2670, Bethesda, MD 20892, USA

  2. 2

    Johnson & Johnson Pharmaceuticals Group, 1125, Trenton-HarbourtonRoad, E32000, Titusville, NJ 08560, USA

  3. 3

    Experimental Therapeutics, Mood and Anxiety Disorders Research Program, National Institute of Mental Health (NIMH-NIH), Bldg 15K, 15 North Drive, Bethesda, MD 20892-2670, USA

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • novel therapeutic strategies for bipolar disorder;
  • bipolar disorder (BPD), chronic and complex disorder comprising diverse behavioural, cognitive, hedonic and motoric changes over lifetime;
  • dynorphin opioid neuropeptide system - regulating mood, cognition, motor and endocrine functions;
  • Young Mania Rating Scale (YMRS);
  • tricyclic antidepressants (TCA), inducing antidepressant effects via anticholinergic properties;
  • purines, key role in energy metabolism - and neurotransmission regulation;
  • purinergic modulator allopurinol - effective antimanic agent in individuals with mania and hyperuricemia;
  • nicotinic acetylcholine receptor (nAChR) system - well-characterized neurotransmitter system;
  • creatine, key role in brain energy homoeostasis - dysfunction implicated in BPD;
  • Social and Occupational Functioning Assessment Scale (SOFAS)


This chapter contains sections titled:

  • Introduction

  • Intracellular pathways and targets worthy of further study in BPD

  • Conclusion

  • Acknowledgements

  • References