Chapter 8. Neurocognition in Bipolar Disorder

  1. Lakshmi N. Yatham3 and
  2. Mario Maj4
  1. Ivan J. Torres1,3 and
  2. Gin S. Malhi2

Published Online: 13 AUG 2010

DOI: 10.1002/9780470661277.ch8

Bipolar Disorder

Bipolar Disorder

How to Cite

Torres, I. J. and Malhi, G. S. (2010) Neurocognition in Bipolar Disorder, in Bipolar Disorder (eds L. N. Yatham and M. Maj), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470661277.ch8

Editor Information

  1. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

  2. 4

    Department of Psychiatry, University of Naples SUN, Naples, Italy

Author Information

  1. 1

    Riverview Hospital, British Columbia Mental Health and Addictions Services, 2601 Lougheed Highway, Coquitlam, BC V3C 4J2, Canada

  2. 2

    Discipline of Psychiatry, Sydney Medical School, University of Sydney, CADE (Clinical Assessment Diagnostic Evaluation) Clinic, Royal North Shore Hospital, Sydney, Australia

  3. 3

    Department of Psychiatry, The University of British Columbia, Vancouver, Canada

Publication History

  1. Published Online: 13 AUG 2010
  2. Published Print: 1 OCT 2010

ISBN Information

Print ISBN: 9780470721988

Online ISBN: 9780470661277



  • bipolar disorder neurocognition;
  • bipolar disorder, dynamic illness involving - alternation between transient periods of mood instability and symptom remission;
  • impaired cognition - as clinical feature of bipolar disorder;
  • field of clinical neuropsychology - understanding of brain/behaviour relationships in clinical populations;
  • cognitive deficits - associated with mood symptoms;
  • neuropsychological domains - sampled in typical neuropsychological evaluation;
  • cognitive deficits in euthymic patients;
  • cognitive impairments - associated with mood states in bipolar disorder;
  • neuroimaging bipolar disorder cognition;
  • genetic basis of bipolar disorder phenotype - specific candidate genes, are abnormally represented in bipolar disorder


This chapter contains sections titled:

  • Introduction

  • Brief overview of neuropsychological assessment

  • Nature of cognitive impairment in bipolar disorder

  • Cognitive deficits associated with mood symptoms

  • Cognitive deficits in euthymic patients

  • Cognitive deficits in subsets of patients

  • Effects of medication

  • Neuroimaging bipolar disorder cognition

  • Aetiology of cognitive impairment

  • Genetic vulnerability

  • Progressive cognitive decline

  • Clinical significance of cognitive impairments

  • Cognition and functional outcome

  • Neuropsychological assessment in bipolar disorder

  • Treatment strategies for cognitive deficits

  • Conclusions

  • References