Solvation Effects in Supramolecular Recognition
Published Online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd. All rights reserved.
Supramolecular Chemistry: From Molecules to Nanomaterials
How to Cite
Rekharsky, M. and Inoue, Y. 2012. Solvation Effects in Supramolecular Recognition. Supramolecular Chemistry: From Molecules to Nanomaterials. .
- Published Online: 15 MAR 2012
Solvent, or solvation, effect arises from various non–covalent weak interactions of solvent molecules with supramolecular host, guest, and complex, and the supramolecular host-guest association process can be significantly affected or even totally altered by solvation. The solvent effect is a critical function of the host, guest, and solvent involved, and therefore neutral hydrophobic organic guests and hydrophilic metal cations show entirely different solvent dependencies upon complexation. Apparently complicated solvation/desolvation behavior of diverse supramolecular host-guest systems can be rationally understood through the analysis by the Grunwald theory of the compensatory enthalpy–entropy relationship observed for a large set of experimental complexation thermodynamic parameters. The enthalpy–entropy compensation analysis is applicable not only to supramolecular host–guest interactions but also to biological assembling processes as a general tool for globally understanding the solvation behavior in chemistry and biology.
- enthalpy–entropy compensation;
- Grunwald theory