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Solvation Effects in Supramolecular Recognition

Concepts

  1. Mikhail Rekharsky,
  2. Yoshihisa Inoue

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc009

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Rekharsky, M. and Inoue, Y. 2012. Solvation Effects in Supramolecular Recognition. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. Osaka University, Suita, Japan

Publication History

  1. Published Online: 15 MAR 2012

Abstract

Solvent, or solvation, effect arises from various non–covalent weak interactions of solvent molecules with supramolecular host, guest, and complex, and the supramolecular host-guest association process can be significantly affected or even totally altered by solvation. The solvent effect is a critical function of the host, guest, and solvent involved, and therefore neutral hydrophobic organic guests and hydrophilic metal cations show entirely different solvent dependencies upon complexation. Apparently complicated solvation/desolvation behavior of diverse supramolecular host-guest systems can be rationally understood through the analysis by the Grunwald theory of the compensatory enthalpy–entropy relationship observed for a large set of experimental complexation thermodynamic parameters. The enthalpy–entropy compensation analysis is applicable not only to supramolecular host–guest interactions but also to biological assembling processes as a general tool for globally understanding the solvation behavior in chemistry and biology.

Keywords:

  • solvation;
  • desolvation;
  • thermodynamics;
  • enthalpy–entropy compensation;
  • Grunwald theory