NMR Spectroscopy in Solution
Published Online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd. All rights reserved.
Supramolecular Chemistry: From Molecules to Nanomaterials
How to Cite
García, J., Martins, L. G. and Pons, M. 2012. NMR Spectroscopy in Solution. Supramolecular Chemistry: From Molecules to Nanomaterials. .
- Published Online: 15 MAR 2012
Solution NMR provides valuable structural information on supramolecular complexes, the dynamics of their formation, and possible rearrangement between isomeric forms or the interplay between hosts and guests in supramolecular cavities. The atomic resolution of NMR provides direct access to the symmetry properties of supramolecular species. Line shapes in NMR spectra are sensitive to the time scale of dynamic processes. NOESY and ROESY experiments are among the most powerful tools to characterize supramolecular structures, although the dynamics of supramolecular complexes is inextricably mixed in these experiments.
Transient supramolecular interactions between low-molecular-weight-guests and macromolecular hosts detected by solution NMR enable the use of low-molecular-weight spies to report on large, NMR invisible, structures. This concept extends the interfaces between supramolecular chemistry, biomolecular structure, and material sciences.
- supramolecular complexes;
- molecular spies;
- drug screening