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Diffusion Ordered NMR Spectroscopy (DOSY)

Techniques

  1. Alceo Macchioni,
  2. Gianluca Ciancaleoni,
  3. Cristiano Zuccaccia,
  4. Daniele Zuccaccia

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc025

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Macchioni, A., Ciancaleoni, G., Zuccaccia, C. and Zuccaccia, D. 2012. Diffusion Ordered NMR Spectroscopy (DOSY). Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. University of Perugia, Perugia, Italy

Publication History

  1. Published Online: 15 MAR 2012

Abstract

This chapter deals with the applications of diffusion NMR spectroscopy to investigate supramolecular compounds in solution. It is organized in three main sections: (i) brief description of the basic concepts underlying self-diffusion in solution and measurement of the self-diffusion translational coefficient (Dt) by NMR experiments; (ii) critical discussion on the determination of accurate hydrodynamic dimensions (molecular weights) of supramolecular compounds by Dt through the Stokes–Einstein equation; (iii) deduction of thermodynamic self-aggregation parameters using models of indefinite association. Emphasis is given to applications of diffusion NMR spectroscopy to supramolecular chemistry rather than to technical and theoretical aspects. Efforts are made to introduce new, potentially difficult concepts with suitable practical examples in order to facilitate the understanding to nonspecialist readers.

Keywords:

  • diffusion NMR;
  • DOSY;
  • PGSE;
  • PFG;
  • supramolecular chemistry;
  • self-aggregation;
  • self-assembly;
  • hydrodynamic radius;
  • hydrodynamic volume;
  • Stokes-Einstein equation