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Synthetic Peptide-Based Receptors

Molecular Recognition

  1. Stefan Kubik

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc064

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Kubik, S. 2012. Synthetic Peptide-Based Receptors. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. Technische Universität Kaiserslautern, Kaiserslautern, Germany

Publication History

  1. Published Online: 15 MAR 2012

Abstract

Synthetic receptors that are solely or at least partly constructed from peptide segments can be regarded as conceptual links between supramolecular chemistry and biochemistry. Many of these receptors therefore share properties characteristic of both these fields. They can be easily modified by using rational design or combinatorial methods, for example. In addition, binding properties are sensitively dependent on receptor conformation, which is in turn controlled by the sequence of the (amino acid) subunits. In this chapter, successful work in the area of synthetic peptide-derived receptors is presented to illustrate general design principles and the properties that can be achieved. To this end, the receptors are divided into four types: cyclic peptides and cyclic pseudopeptides, conformationally constrained cyclic peptides containing rigid nonnatural subunits, linear peptides with natural and/or nonnatural subunits, and conjugates of abiotic receptors and peptide-based subunits. The examples demonstrate that not only are peptide-derived receptors excellent mimics for natural ligands but in some cases they also possess outstanding binding properties when compared to the other types of synthetic receptors studied in supramolecular chemistry.

Keywords:

  • synthetic receptors;
  • molecular recognition;
  • amino acids;
  • peptides;
  • cyclopeptides