Published Online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd. All rights reserved.
Supramolecular Chemistry: From Molecules to Nanomaterials
How to Cite
Cavalli, S., Robson Marsden, H., Albericio, F. and Kros, A. 2012. Peptide Self-Assembly. Supramolecular Chemistry: From Molecules to Nanomaterials. .
- Published Online: 15 MAR 2012
The formation of well-ordered nanostructures by a process of self-association in aqueous media or at interfaces represents the core of modern nanotechnology. Processes of molecular recognition and self-assembly direct the way in which relatively simple building blocks recognize each other, associate, and form ordered one-, two-, and three-dimensional structures with a wide range of applications in nanoscience. The manner in which molecules self-assemble and their interaction energies, shapes, and ultimate functions can be programmed at the molecular level by a careful and rational design. Peptides are among the most powerful building blocks available for constructing “smart” well-ordered nanostructures in a “bottom-up” approach, as they possess the biocompatibility and chemical diversity that are commonly found in proteins, but they are much more stable and robust and can be readily synthesized on a large scale. In this chapter, the main categories of peptide amphiphiles are discussed for their ability to spontaneously associate to form a variety of nanostructures (e.g., tubes, spheres, fibrils, tapes, and hydrogels at the nanometerscale) and some key features of this processes are outlined by describing a selection of relevant published works.
- amphiphilic peptide;
- building block;