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Designing Peptide-Based Supramolecular Biomaterials

Soft Matter

  1. Vineetha Jayawarna,
  2. Rein V. Ulijn

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc151

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Jayawarna, V. and Ulijn, R. V. 2012. Designing Peptide-Based Supramolecular Biomaterials. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. University of Strathclyde, Glasgow, UK

Publication History

  1. Published Online: 15 MAR 2012


One rapidly emerging area where supramolecular chemistry can have a significant impact is in biomaterials science, and specifically in the design of cell-contacting biomaterials. Aspects that are known to influence cell behavior at any particular time include chemical signals, mechanical properties (i.e., gel stiffness), and topographical signals related to fiber sizes and alignment. In this chapter, we provide an overview of current supramolecular chemistry strategies in the design of cell scaffolds based on peptides and their derivatives. The approaches discussed include those inspired by secondary or quaternary structures (α-helix, β-sheet, collagen triple helix) found in natural proteins as well as synthetic sequences such as aromatic and aliphatic peptide amphiphiles. We then discuss how supramolecular fibers based on peptides can be designed to control and direct (stem) cell behavior by engineering stiffness and chemical presentation of bioactive ligands.


  • peptide;
  • hydrogel;
  • self-assembly;
  • supramolecular material;
  • biomaterials chemistry