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Reaction Networks

Supramolecular Reactivity

  1. Zehavit Dadon,
  2. Nathaniel Wagner,
  3. Rivka Cohen-Luria,
  4. Gonen Ashkenasy

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc162

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Dadon, Z., Wagner, N., Cohen-Luria, R. and Ashkenasy, G. 2012. Reaction Networks. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. Ben Gurion University of the Negev, Beer Sheva, Israel

Publication History

  1. Published Online: 15 MAR 2012


The study of synthetic molecular networks is of fundamental importance for understanding the organizational principles of biological systems. An important family of the nonenzymatic systems uses template-directed catalysis as a means of wiring the network components and controlling their dynamics and replication. As such, these networks have received considerable attention with respect to possible scenarios in the origins of life and early molecular evolution. In this review, we summarize recent studies aimed at the design and functional analysis of peptide-based replicating networks. Design of the networks, by simultaneous implementation of autocatalysis and cross-catalysis, is first explained. It is followed by detailing how one can simulate the complex networks' kinetics, and how it is possible to manipulate the catalytic processes and thus to control the entire network topology. At the end, we discuss the relevancy of these findings to the study of biochemical networks, such as RNA networks.


  • molecular replication;
  • synthetic networks;
  • self-organization;
  • peptides;
  • logic gates