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Rational Design of Peptide-Based Biosupramolecular Systems

Supramolecular Aspects of Chemical Biology

  1. Aimee L. Boyle,
  2. Derek N. Woolfson

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc168

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Boyle, A. L. and Woolfson, D. N. 2012. Rational Design of Peptide-Based Biosupramolecular Systems. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. University of Bristol, Bristol, UK

Publication History

  1. Published Online: 15 MAR 2012

Abstract

The de novo design of systems comprising peptides and proteins as building blocks presents exciting new challenges in the areas of self-assembly and supramolecular chemistry and biochemistry. A key issue is that the rules relating protein sequence-to-structure are not fully elucidated. However, through the use of rational, “bottom-up” approaches, systems can be constructed by the careful design and programming of peptidic tectons that use existing sequence-to-structure relationships and test new ones. Indeed, there has been considerable success in the design and development of effectively infinite, fibrous systems constructed from α-helical, β-structured or collagen-based tectons. Some designs are now well enough developed that they can be readily functionalized, leading to potential applications in bionanotechnology, synthetic biology, and tissue engineering.

The design of discrete assemblies using similar approaches, however, is proving more challenging, with precise control of assembly being particularly difficult. As a result, there are fewer examples of such systems being reduced to practice.

This chapter describes design rules and approaches exemplified with fibrous and discrete systems, as well as discussing routes to the functionalization of such assemblies and their potential applications.

Keywords:

  • peptide;
  • protein;
  • self-assembly;
  • nanostructure;
  • supramolecular;
  • discrete;
  • de novo design