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Supramolecular Chemistry in In Vitro Biosensors

Supramolecular Aspects of Chemical Biology

  1. Jing Sun,
  2. Min Cai,
  3. John J. Lavigne

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc177

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Sun, J., Cai, M. and Lavigne, J. J. 2012. Supramolecular Chemistry in In Vitro Biosensors. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. University of South Carolina, Columbia, SC, USA

Publication History

  1. Published Online: 15 MAR 2012

Abstract

Supramolecular chemistry has greatly impacted the development of biosensors for use in vitro. On the one hand, supramolecular materials can be used as the recognition elements or transducers in these biosensors. On the other hand, the supramolecular interactions between a host and a guest are fundamental in defining the recognition, and can be utilized to develop new sensing mechanisms or improve sensor performance. This chapter focuses on sensing motifs and sensing platforms used in vitro for the detection of biologically relevant targets. The highlighted biosensors are based on small molecules, polymers, and biological molecule-nanomaterial hybrids. Detection methods presented herein primarily focus on optical, electrochemical, or mass-sensitive modes.

Keywords:

  • supramolecular chemistry;
  • biosensor;
  • macrocycle;
  • polymer;
  • biological molecule-nanomaterial hybrid