Aptamer Moieties in Biochemical Applications
Published Online: 15 MAR 2012
Copyright © 2012 John Wiley & Sons, Ltd. All rights reserved.
Supramolecular Chemistry: From Molecules to Nanomaterials
How to Cite
Donovan, M. J., Meng, L., Gulbakan, B., Chen, Y., Parekh, P., Sefah, K. and Tan, W. 2012. Aptamer Moieties in Biochemical Applications. Supramolecular Chemistry: From Molecules to Nanomaterials.
- Published Online: 15 MAR 2012
Aptamers developed for applications in cancer therapy can improve the efficacy of drug treatment and enhance imaging. Aptamers for these purposes are generated from a process known as SELEX (systematic evolution of ligands by exponential enrichment), or, more precisely when biological cells are used, cell-based SELEX. Aptamers provide a highly target-specific means of transporting drugs to cancer cells. Improved imaging is also possible when aptamers are coupled with micelles, nanomaterials, or hydrogels. These aptamer conjugates show great ability as molecular probes in a variety of applications.
Keywords: aptamers; molecular conjugate; cancer cells; drug development; conjugation