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Supramolecular Nanoparticles for Molecular Diagnostics and Therapeutics

Nanotechnology

  1. Kuan-Ju Chen,
  2. Mitch André Garcia,
  3. Hao Wang,
  4. Hsian-Rong Tseng

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc194

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Chen, K.-J., Garcia, M. A., Wang, H. and Tseng, H.-R. 2012. Supramolecular Nanoparticles for Molecular Diagnostics and Therapeutics. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. University of California, Los Angeles, CA, USA

Publication History

  1. Published Online: 15 MAR 2012

Abstract

The application of nanoparticles toward diagnostics and therapeutics offers many advantages over traditional methods; as a result, this burgeoning field has attracted researchers from the fields of chemistry, engineering, and biology to explore their use in solving clinically relevant problems. Various approaches to generate nanoparticles have been investigated by many researchers, and some promising systems are explored in this chapter. However, many nanoparticle platforms still involve time-consuming synthetic steps, which limits the ease of generating a diverse library of nanoparticles that have unique surface chemistry and different sizes. This chapter explores nanoparticle-based diagnostics with examples from the literature involving in vivo lymphatic drainage experiments, and protein detection. Some examples of nanoparticle-based therapeutics will be investigations of laser-induced photothermal treatment of cancer cells from gold nanoparticles, gene transfection experiments using nanoparticles as a nonviral gene carrier, drug delivery using a drug-conjugated polymer system, and an example of a clinical trial where nanoparticles are used to deliver siRNA. We anticipate that nanoparticles will establish a new pathway to further facilitate the development of molecular diagnostics and therapeutics. We believe that the inherent advantages that nanoparticle platforms can deliver will pave the way toward personalized medicine and translational clinic.

Keywords:

  • nanoparticles;
  • diagnostics;
  • therapeutics;
  • self-assembly;
  • microfluidics