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Supramolecular Hybrid Nanomaterials As Prospective Sensing Platforms


  1. Mustafa Biyikal1,
  2. Mandy Hecht1,
  3. Ramón Martínez-Máñez2,3,
  4. Knut Rurack1,
  5. Félix Sancenón2,3

Published Online: 15 MAR 2012

DOI: 10.1002/9780470661345.smc199

Supramolecular Chemistry: From Molecules to Nanomaterials

Supramolecular Chemistry: From Molecules to Nanomaterials

How to Cite

Biyikal, M., Hecht, M., Martínez-Máñez, R., Rurack, K. and Sancenón, F. 2012. Supramolecular Hybrid Nanomaterials As Prospective Sensing Platforms. Supramolecular Chemistry: From Molecules to Nanomaterials. .

Author Information

  1. 1

    BAM Bundesanstalt für Materialforschung und—prüfung, Berlin, Germany

  2. 2

    Unidad Mixta Universidad Politécnica de Valencia—Universidad de Valencia, Universidad Politécnica de Valencia, Valencia, Spain

  3. 3

    CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Aragon, Spain

Publication History

  1. Published Online: 15 MAR 2012


Supramolecular interactions are vital processes in many chemical sensors, biochemical assays, and other analytical detection schemes. On the background of the current, rapidly developing, and constantly changing requirements for (bio)analytical techniques, the classical molecular host is increasingly overburdened to accomplish a specific analytical task with the desired selectivity and sensitivity. Instead, other signaling strategies have to be conceived that overcome the limits in signal output, dynamic range, or compound targeting, which are imminent to various traditional methods. A very promising approach is the combination of concepts of supramolecular chemistry with nanostructured or nanoscopic inorganic materials, that is, the development of hybrid sensor materials. Such hybrids often lead to improved functionality and enhanced performance, and the present chapter discusses the contributory features in relation to the major aspects, which are related to the enhanced coordination by the preorganization of binding sites, signal amplification by the preorganization on surfaces, aggregation-mediated signaling, surface-modification-based signaling, the tuning of selectivity through polarity and size, and gated signaling.


  • fluorescence;
  • hybrid nanomaterials;
  • optical sensors;
  • redox sensors;
  • supramolecular chemistry