Chapter 15. Frameworks for Programming RNA Devices

  1. Günter Mayer
  1. Maung Nyan Win,
  2. Joe C. Liang and
  3. Christina D. Smolke

Published Online: 14 MAY 2010

DOI: 10.1002/9780470664001.ch15

The Chemical Biology of Nucleic Acids

The Chemical Biology of Nucleic Acids

How to Cite

Win, M. N., Liang, J. C. and Smolke, C. D. (2010) Frameworks for Programming RNA Devices, in The Chemical Biology of Nucleic Acids (ed G. Mayer), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470664001.ch15

Editor Information

  1. Strathclyde Institute for Pharmacy and Biological Sciences, University of Strathclyde, 27 Taylor Street, Glasgow G4 0NR, UK

Author Information

  1. Department of Bioengineering, 473 Via Ortega, MC 4201, Stanford University, Stanford, CA 94305, USA

Publication History

  1. Published Online: 14 MAY 2010
  2. Published Print: 28 MAY 2010

ISBN Information

Print ISBN: 9780470519745

Online ISBN: 9780470664001



  • frameworks for programming RNA devices;
  • RNA - providing programmable molecular substrate;
  • RNA parts basic functions;
  • RNA devices - encoding complex functions;
  • RNA device design strategies - sensor and actuator parts - direct coupling;
  • RNA device design strategies - distinct information and transmission function integration;
  • frameworks functional composition - device design strategies;
  • composition frameworks - supporting higher order device functions;
  • RNA devices engineering technologies;
  • RNA parts and devices composed engineered systems


This chapter contains sections titled:

  • Introduction

  • RNA provides a functionally diverse and programmable molecular substrate

  • RNA parts exhibit basic functions

  • RNA devices are composed of distinct parts and encode more complex functions

  • RNA device design strategies based on the direct coupling of sensor and actuator parts

  • RNA device design strategies based on the integration of a distinct information transmission function

  • Functional composition frameworks support device design strategies based on modular assembly of RNA parts

  • Composition frameworks support extensions to higher order device functions

  • Enabling technologies that support the engineering of RNA devices

  • Engineered systems composed of RNA parts and devices

  • Conclusion

  • References