Chapter 13. Proteins as Host for Enantioselective Catalysis: Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology

  1. Udo H. Brinker and
  2. Jean-Luc Mieusset
  1. Jincheng Mao and
  2. Thomas R. Ward

Published Online: 13 JUL 2010

DOI: 10.1002/9780470664872.ch13

Molecular Encapsulation: Organic Reactions in Constrained Systems

Molecular Encapsulation: Organic Reactions in Constrained Systems

How to Cite

Mao, J. and Ward, T. R. (2010) Proteins as Host for Enantioselective Catalysis: Artificial Metalloenzymes Based on the Biotin–Streptavidin Technology, in Molecular Encapsulation: Organic Reactions in Constrained Systems (eds U. H. Brinker and J.-L. Mieusset), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470664872.ch13

Editor Information

  1. Institut für Organische Chemie, Universität Wien, A–1090 Wien, Austria

Author Information

  1. Department of Chemistry, University of Basel, CH-4056, Basel Switzerland

Publication History

  1. Published Online: 13 JUL 2010
  2. Published Print: 25 JUN 2010

ISBN Information

Print ISBN: 9780470998076

Online ISBN: 9780470664872

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Keywords:

  • proteins as host for enantioselective catalysis - artificial metalloenzymes based on biotin-streptavidin technology;
  • biotin-avidin technology - chemical optimization dimension;
  • genetic optimization dimension;
  • artificial hydrogenases;
  • artificial allylic alkylases;
  • artificial transfer hydrogenase;
  • organometallic moiety localization within macromolecular host - anchoring strategies, covalent, dative or supramolecular;
  • enantioselective sulfoxidation - based on vanadyl-loaded streptavidin;
  • artificial metalloenzyme and biotin-avidin technology - versatile approach to enantioselective catalysis

Summary

This chapter contains sections titled:

  • Introduction

  • The Biotin–Avidin Technology

  • Artificial Hydrogenases

  • Artificial Allylic Alkylases

  • Artificial Transfer Hydrogenase

  • Enantioselective Sulfoxidation Based on Vanadyl-loaded Streptavidin

  • Conclusions and Outlook

  • Acknowledgements

  • References