10. Pharmacogenetics and Pharmacogenomics

  1. Stephen H. Curry Professor Fellow1 and
  2. Robin Whelpton PhD research assistant Professor senior lecturer member2

Published Online: 29 OCT 2010

DOI: 10.1002/9780470665190.ch10

Drug Disposition and Pharmacokinetics: From Principles to Applications

Drug Disposition and Pharmacokinetics: From Principles to Applications

How to Cite

Curry, S. H. and Whelpton, R. (2010) Pharmacogenetics and Pharmacogenomics, in Drug Disposition and Pharmacokinetics: From Principles to Applications, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470665190.ch10

Author Information

  1. 1

    University of Rochester, USA

  2. 2

    Queen Mary University of London, UK

Publication History

  1. Published Online: 29 OCT 2010
  2. Published Print: 25 OCT 2010

ISBN Information

Print ISBN: 9780470684467

Online ISBN: 9780470665190

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Keywords:

  • pharmacogenetics and pharmacogenomics;
  • drug response genetic differences - and differences in drug disposition pharmacodynamics;
  • genes, sequences of nucleic acids on chromosomes - traits of organism;
  • single-nucleotide polymorphism(SNP) - amino acid substituted for another;
  • phenotyping, systematically done - drugs as ‘probes’ determining subject's metabolizer status;
  • substances, and phenotype individuals - drug metabolizing activity;
  • Cytochrome P450 polymorphisms;
  • microsomal drug metabolizing enzyme polymorphism - exaggerated response to obsolete antihypertensive, debrisoquine;
  • thiopurine methyltransferase (TPMT) phenotyping or genotyping - azathioprine treatment, avoiding acute toxicity

Summary

This chapter contains sections titled:

  • Introduction

  • Methods for the study of pharmacogenetics

  • N-Acetyltransferase

  • Plasma cholinesterase

  • Cytochrome P450 polymorphisms

  • Alcohol dehydrogenase and acetaldehyde dehydrogenase

  • Thiopurine methyltransferase

  • Phase 2 enzymes

  • Transporters

  • Pharmacodynamic differences

  • References and Further Reading