11. Developmental Pharmacology and Age-Related Phenomena

  1. Stephen H. Curry Professor Fellow1 and
  2. Robin Whelpton PhD research assistant Professor senior lecturer member2

Published Online: 29 OCT 2010

DOI: 10.1002/9780470665190.ch11

Drug Disposition and Pharmacokinetics: From Principles to Applications

Drug Disposition and Pharmacokinetics: From Principles to Applications

How to Cite

Curry, S. H. and Whelpton, R. (2010) Developmental Pharmacology and Age-Related Phenomena, in Drug Disposition and Pharmacokinetics: From Principles to Applications, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470665190.ch11

Author Information

  1. 1

    University of Rochester, USA

  2. 2

    Queen Mary University of London, UK

Publication History

  1. Published Online: 29 OCT 2010
  2. Published Print: 25 OCT 2010

ISBN Information

Print ISBN: 9780470684467

Online ISBN: 9780470665190



  • developmental pharmacology and age-related phenomena;
  • physiological and pharmacokinetic processes;
  • intramuscular injections - and changes in muscle blood flow, in first days of life;
  • blood–brain barrier, immature at birth - full development by 6 months;
  • CYP-450 isoform changes - during life cycle;
  • age-related variation of CYP2D6 protein - in human liver;
  • creatinine clearance, body weight - highly depressed in premature newborns, and depressed in neonate;
  • metabolic and pharmacodynamic phenomena;
  • Documenta Geigy Scientific Tables;
  • data compilations - in Goodman and Gilman's The Pharmacological Basis of Therapeutics


This chapter contains sections titled:

  • Introduction

  • Scientific and regulatory environment in regard to younger and older patients

  • Terminology

  • Physiological and pharmacokinetic processes

  • Body surface area versus weight

  • Age groups

  • Further examples

  • Further reading and references