15. Management of Advanced Heart Failure

  1. Barry H. Greenberg2,
  2. Denise D. Barnard2,
  3. Sanjiv M. Narayan3 and
  4. John R. Teerlink4,5
  1. Ronald Freudenberger MD

Published Online: 14 SEP 2010

DOI: 10.1002/9780470669402.ch15

Management of Heart Failure

Management of Heart Failure

How to Cite

Freudenberger, R. (2010) Management of Advanced Heart Failure, in Management of Heart Failure (eds B. H. Greenberg, D. D. Barnard, S. M. Narayan and J. R. Teerlink), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470669402.ch15

Editor Information

  1. 2

    Division of Cardiology, University of California, San Diego, California, USA

  2. 3

    University of California and Veterans Affairs Medical Center, San Diego, California, USA

  3. 4

    Section of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA

  4. 5

    School of Medicine, University of California, San Francisco, California, USA

Author Information

  1. Division of Cardiology, Penn State College of Medicine, Allentown, Pennsylvania, USA

Publication History

  1. Published Online: 14 SEP 2010
  2. Published Print: 8 OCT 2010

ISBN Information

Print ISBN: 9780470753798

Online ISBN: 9780470669402



  • advanced heart failure management;
  • advanced ACC/AHA Stage D heart failure (HF) - patients with truly refractory HF;
  • beta-blocking agents;
  • pharmacologic therapy - in patients with stage D heart failure;
  • ACC/AHA Current Recommendations for patients - with Refractory end-stage Heart Failure (Stage D);
  • event-free survival, in Carvedilol Prospective Randomized cumulative Survival (COPERNICUS) study;
  • cardiac resynchronization therapy;
  • implantable cardioverter defibrillator;
  • coronary artery bypass grafting (CABG) - for ischemic cardiomyopathy;
  • INTERMACS Patient Profiles and Timing of Mechanical Circulatory Support


This chapter contains sections titled:

  • Definition

  • Pharmacologic therapy in patients with stage D heart failure

  • Device management

  • Surgical options

  • Special considerations and end of life issues

  • Conclusion

  • References