4. Neurohormonal Blocking Agents in the Treatment of Patients with Left Ventricular Dysfunction and Heart Failure

  1. Barry H. Greenberg1,
  2. Denise D. Barnard1,
  3. Sanjiv M. Narayan2,
  4. John R. Teerlink3,4
  1. Ruchika Dutta MD,
  2. Barry H. Greenberg MD

Published Online: 14 SEP 2010

DOI: 10.1002/9780470669402.ch4

Book Title

Management of Heart Failure

Management of Heart Failure

Additional Information

How to Cite

Dutta, R. and Greenberg, B. H. (2010) Neurohormonal Blocking Agents in the Treatment of Patients with Left Ventricular Dysfunction and Heart Failure, in Management of Heart Failure (eds B. H. Greenberg, D. D. Barnard, S. M. Narayan and J. R. Teerlink), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470669402.ch4

Editor Information

  1. 1

    Division of Cardiology, University of California, San Diego, California, USA

  2. 2

    University of California and Veterans Affairs Medical Center, San Diego, California, USA

  3. 3

    Section of Cardiology, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA

  4. 4

    School of Medicine, University of California, San Francisco, California, USA

Author Information

  1. Division of Cardiology, University of California, San Diego, California, USA

Publication History

  1. Published Online: 14 SEP 2010
  2. Published Print: 8 OCT 2010

ISBN Information

Print ISBN: 9780470753798

Online ISBN: 9780470669402

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CHAPTER TOOLS

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Keywords:

  • treatment modalities;
  • neurohormonal blocking agents, in treatment of patients with left ventricular dysfunction and heart failure;
  • neurohormonal activation involvement - in pathogenesis and progression of heart failure;
  • neurohormonal pathways and sites of action - of pharmacologic agents;
  • beta-adrenergic blocking agents (beta-blockers);
  • clinical trials with beta-blockers;
  • pharmacologic properties - of beta-blockers;
  • LV remodeling improvement - with metoprolol succinate in REVERT study;
  • hypotension management - associated with beta-blocker, ACEI, or ARB use;
  • angiotensin receptor blockers (ARBs) - alternative mechanism of blocking

Summary

This chapter contains sections titled:

  • Introduction

  • Practical approach to treating patients with beta-blockers

  • Angiotensin-converting enzyme inhibitors (ACEIs)

  • Practical approach to treating patients with ACE inhibitors

  • Angiotensin receptor blockers (ARBs)

  • Practical approach to treating patients with ARBs

  • Practical approach to treatment of patients with aldosterone antagonists

  • References

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