76. Mood Disorders in Parkinson's Disease

  1. Mohammed T. Abou-Saleh2,
  2. Cornelius Katona3 and
  3. Anand Kumar4
  1. John V. Hindle

Published Online: 10 DEC 2010

DOI: 10.1002/9780470669600.ch76

Principles and Practice of Geriatric Psychiatry, Third Edition

Principles and Practice of Geriatric Psychiatry, Third Edition

How to Cite

Hindle, J. V. (2010) Mood Disorders in Parkinson's Disease, in Principles and Practice of Geriatric Psychiatry, Third Edition (eds M. T. Abou-Saleh, C. Katona and A. Kumar), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470669600.ch76

Editor Information

  1. 2

    Division of Mental Health, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK

  2. 3

    Department of Mental Health Sciences, University College London, Charles Bell House, 7-73 Riding House Street, London WIW 7EJ, UK

  3. 4

    Department of Psychiatry, University of Illinois-Chicago, 912 South Wood Street, Chicago, IL 60637, USA

Author Information

  1. School of Medical Sciences, University of Bangor, Llandudno Hospital, Llandudno, Conwy, LL30 1LB, UK

Publication History

  1. Published Online: 10 DEC 2010
  2. Published Print: 17 DEC 2010

ISBN Information

Print ISBN: 9780470747230

Online ISBN: 9780470669600



  • mood disorders - in Parkinson's disease;
  • Parkinson's disease, second cause - of chronic neurological disability after stroke;
  • Parkinson's disease and depression - spectrum of mood disturbances, and mood changes;
  • depression in Parkinson's disease - psychiatric non-motor symptom of Parkinson's disease;
  • depressive symptoms - in elderly patients;
  • cognitive impairment in Parkinson's disease - risk factor for depression, and depressive–executive syndrome;
  • principles of management of depression - in chronic physical health problemsm, in guideline Depression with a Chronic Physical Health Problem published by NICE;
  • selective serotonin re-uptake inhibitor (SSRI) antidepressants - first-line treatment in depression in Parkinson's disease;
  • subsyndromal and mild cases - a watch and wait approach appropriate


“Parkinson's disease (PD) is the second commonest cause of chronic neurological disability after stroke. The prevalence of PD increases with increasing age and in the UK is ∼150 per 100 000 population with incidence of 10.8 cases of PD per 100 000 population. The mean age of onset of PD is in the seventies. The diagnosis of PD is based on the presence of bradykinesia, rest tremor, rigidity, and loss of postural reflexes all of which are likely to be asymmetrical. It is now recognised that PD is much more than a motor disorder, having a spectrum of non-motor symptoms, which may occur prior to the onset of the motor signs. The non-motor symptoms of PD may have more impact on long term quality of life compared with the motor symptoms1. Non motor symptoms include autonomic impairment (eg constipation, sweating, urinary problems, dribbling and dysphagia) psychiatric problems (eg depression, dementia, psychosis), sleep disturbances (eg sleep behaviour disorder), sensory disturbances, nutritional problems and problems of balance and falls.

This chapter will focus on the depression in PD (dPD) which is the most common psychiatric non-motor symptom of PD. dPD is associated with a poor quality of life, excess disability, carer stress and treatment of depression can reduce functional disability”