Chapter 1. Knowledge-Based Bioinformatics

  1. Gil Alterovitz and
  2. Marco Ramoni
  1. Eric Karl Neumann

Published Online: 7 JUL 2010

DOI: 10.1002/9780470669716.ch1

Knowledge-Based Bioinformatics: From Analysis to Interpretation

Knowledge-Based Bioinformatics: From Analysis to Interpretation

How to Cite

Neumann, E. K. (2010) Knowledge-Based Bioinformatics, in Knowledge-Based Bioinformatics: From Analysis to Interpretation (eds G. Alterovitz and M. Ramoni), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470669716.ch1

Editor Information

  1. Harvard Medical School and Massachusetts Institute of Technology, Boston, USA

Author Information

  1. Clinical Semantics Group, Lexington, MA, USA

Publication History

  1. Published Online: 7 JUL 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470748312

Online ISBN: 9780470669716

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Keywords:

  • aggregation;
  • bioinformatics;
  • biomedical data analysis;
  • biomedical informatics;
  • classification;
  • data management;
  • data mining;
  • drug development;
  • logical inference;
  • information extraction;
  • gene expression analysis;
  • genome wide associations;
  • genotype to phenotype;
  • knowledge discovery;
  • knowledge driven applications;
  • knowledge representation;
  • linked data;
  • medical informatics;
  • ontologies;
  • pattern recognition;
  • reasoning;
  • statistical data analysis;
  • semantic web;
  • text mining;
  • therapeutic R&D

Summary

This chapter contains sections titled:

  • Introduction

  • Formal reasoning for bioinformatics

  • Knowledge representations

  • Collecting explicit knowledge

  • Representing common knowledge

  • Capturing novel knowledge

  • Knowledge discovery applications

  • Semantic harmonization: the power and limitation of ontologies

  • Text mining and extraction

  • Gene expression

  • Pathways and mechanistic knowledge

  • Genotypes and phenotypes

  • The Web's role in knowledge mining

  • New frontiers

  • References