Chapter 8. Fundamentals of Gene Ontology Functional Annotation

  1. Gil Alterovitz and
  2. Marco Ramoni
  1. Varsha K. Khodiyar1,
  2. Emily C. Dimmer2,
  3. Rachael P. Huntley2 and
  4. Ruth C. Lovering1

Published Online: 7 JUL 2010

DOI: 10.1002/9780470669716.ch8

Knowledge-Based Bioinformatics: From Analysis to Interpretation

Knowledge-Based Bioinformatics: From Analysis to Interpretation

How to Cite

Khodiyar, V. K., Dimmer, E. C., Huntley, R. P. and Lovering, R. C. (2010) Fundamentals of Gene Ontology Functional Annotation, in Knowledge-Based Bioinformatics: From Analysis to Interpretation (eds G. Alterovitz and M. Ramoni), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470669716.ch8

Editor Information

  1. Harvard Medical School and Massachusetts Institute of Technology, Boston, USA

Author Information

  1. 1

    Centre for Cardiovascular Genetics, University College London, UK

  2. 2

    European Bioinformatics Institute, Cambridge, UK

Publication History

  1. Published Online: 7 JUL 2010
  2. Published Print: 16 JUL 2010

ISBN Information

Print ISBN: 9780470748312

Online ISBN: 9780470669716

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Keywords:

  • UniProt Knowledgebase (UniProtKB);
  • Kyoto Encyclopedia of Genes and Genomes KEGG;
  • Human Unidentified Gene-Encoded Large Proteins HUGE;
  • Gene Ontology and the annotation of the human proteome;
  • Saccharomyces Genome Database (SGD);
  • Comparative genomics and electronic protein annotation;
  • Manual methods of transferring functional annotation;
  • ‘Inferred by Sequence or structural Similarity’ (ISS)

Summary

This chapter contains sections titled:

  • Introduction

  • Gene Ontology (GO)

  • Comparative genomics and electronic protein annotation

  • Community annotation

  • Limitations

  • Accessing GO annotations

  • Conclusions

  • References