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Biomimetic Fe(II) Chemistry and Synthetic Studies on Antimalarial and Antitumour Endoperoxides

Peroxides (2006)

  1. Paul M. O'Neill,
  2. James Chadwick,
  3. Sarah L. Rawe

Published Online: 15 DEC 2009

DOI: 10.1002/9780470682531.pat0363

Patai's Chemistry of Functional Groups

Patai's Chemistry of Functional Groups

How to Cite

O'Neill, P. M., Chadwick, J. and Rawe, S. L. 2009. Biomimetic Fe(II) Chemistry and Synthetic Studies on Antimalarial and Antitumour Endoperoxides. Patai's Chemistry of Functional Groups.

Author Information

  1. University of Liverpool, Department of Chemistry, The Robert Robinson Laboratories, Liverpool, UK

Publication History

  1. Published Online: 15 DEC 2009

Abstract

  • 1
    Introduction
  • 2
    Endoperoxide-Containing Antimalarials
  • 3
    The Role of Iron
  • 4
    The Biological Targets of Antimalarial Endoperoxides
  • 5
    Semi-Synthetic Artemisinin Derivatives
  • 6
    Synthetic Endoperoxides
  • 7
    Antimalarial Activities of Synthetic Endoperoxide Antimalarials
  • 8
    Endoperoxide Containing Compounds with Antitumour Activity

Keywords:

  • endoperoxide-containing antimalarials;
  • Artemisia annua and artemisinin;
  • hematin aggregation process and role of iron;
  • Histidine Rich Protein (HRP);
  • biomimetic Fe(II) chemistry and synthetic studies;
  • antimalarial endoperoxide biological target;
  • semi-synthetic artemisinin derivatives;
  • artemisinins as antitumour agents