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Organoselenium and organotellurium compounds: Toxicology and pharmacology

Organic Selenium and Tellurium Compounds (2012)

  1. Cristina W. Nogueira,
  2. João B. T. Rocha

Published Online: 15 APR 2011

DOI: 10.1002/9780470682531.pat0567

Patai's Chemistry of Functional Groups

Patai's Chemistry of Functional Groups

How to Cite

Nogueira, C. W. and Rocha, J. B. T. 2011. Organoselenium and organotellurium compounds: Toxicology and pharmacology. Patai's Chemistry of Functional Groups. .

Author Information

  1. Laboratório de Síntese, Reatividade e Avaliacão Farmacológica e Toxicológica de Organocalcogênios, RS, Brazil

Publication History

  1. Published Online: 15 APR 2011

Abstract

In the last three decades, the interest in the field of synthesis and reactivity of organoselenium and organotellurium compounds has increased; particularly, in view of the observations that they can exhibit important biological activities. The data presented in this chapter clearly indicate the potential pharmacological and therapeutic uses of organoselenium and organotellurium compounds. Indeed, these classes of molecules exhibit a variety of interesting biological effects, namely antioxidant properties, which can account for their in vitro and in vivo beneficial effects in a wide range of models of different human pathologies. We can conclude that the future of “medicinal chemistry“ of organoselenium and organotellurium compounds will depend on the rational development of new molecules, which can be guided by chemical and biological approaches. Moreover, the structure-activity relationship for a given class of organoselenium or organotellurium compounds should be used as a toll for screening molecules with high probability of exhibiting low toxicity and high pharmacological activity in mammals.

Keywords:

  • selenium;
  • tellurium;
  • organoselenium;
  • organotellurium;
  • toxicology;
  • pharmacology;
  • thiol