The Chemistry of Selenocysteine
Organic Selenium and Tellurium Compounds (2012)
Published Online: 15 DEC 2011
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
Patai's Chemistry of Functional Groups
How to Cite
Metanis, N., Beld, J. and Hilvert, D. 2011. The Chemistry of Selenocysteine. Patai's Chemistry of Functional Groups.
- Published Online: 15 DEC 2011
Selenocysteine is a redox active amino acid. It is inserted co-translationally into a number of natural proteins, providing them with a range of interesting enzymatic activities; it can also be incorporated into artificial peptides and proteins as a structural and mechanistic probe. In this chapter, the chemistry and biochemistry of this novel amino acid is reviewed. In addition to the (bio)synthesis of selenocysteine, selenopeptides and selenoproteins, the roles selenium plays in enzyme catalysis and its utility for diverse biotechnological applications are discussed.
- stop codon suppression;
- redox chemistry