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Biomimetic Metal Phenolates

Metal Phenolates (2013)

  1. Gabriella Tamasi,
  2. Renzo Cini

Published Online: 28 APR 2014

DOI: 10.1002/9780470682531.pat0612

Patai's Chemistry of Functional Groups

Patai's Chemistry of Functional Groups

How to Cite

Tamasi, G. and Cini, R. 2014. Biomimetic Metal Phenolates. Patai's Chemistry of Functional Groups. 1–58.

Author Information

  1. Università di Siena, Dipartimento di Chimica, Via Alcide de Gasperi 2, I-53100 Siena, Italy Fax: +39 0577 234254;e-mail: tamasi@unisi.it and renzo.cini@unisi.it

Publication History

  1. Published Online: 28 APR 2014

Abstract

The chapter reports on recent studies of metal complexes that have the phenolate group as a ligand. The synthesis and characterization of many low molecular weight complexes is reviewed and commented on. Special attention is devoted to biomimetic models, for a deeper understanding of metalloprotein structures and functions. The chapter is divided into two parts, related to oxidant and antioxidant activities and to the hydrolysis of phospatediesters, respectively.

Activity of phenols as antioxidants and VIVO2+, MnII, MnIII, MnIV,CoII, CoIII, NiII, CuI, CuII and ZnII complexes with phenolato-containing Schiff bases as biomimetic for biological systems, is the focus of the first part. A section is dedicated to selected CuII and PtII complexes having pharmaceutical active molecules as ligands, from the OXICAM family of non-steroidal anti-inflammatory drugs. The second part reports on metal–phenolato complexes as models for phosphodiesterase enzymes. Dinuclear complexes based on ZnII, FeIII/ZnII, ZnII/MgII metal centers are reviewed and commented on

Keywords:

  • phenolate ligands;
  • metal complexes;
  • biomimetics;
  • metalloproteins;
  • antioxidant activity;
  • phosphate hydrolysis;
  • Oxicam drugs