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Iron-Catalyzed Cross-Coupling Reactions

Organoiron Compounds (2013)

  1. Laurean Ilies,
  2. Eiichi Nakamura

Published Online: 22 OCT 2012

DOI: 10.1002/9780470682531.pat0651

Patai's Chemistry of Functional Groups

Patai's Chemistry of Functional Groups

How to Cite

Ilies, L. and Nakamura, E. 2012. Iron-Catalyzed Cross-Coupling Reactions. Patai's Chemistry of Functional Groups. .

Author Information

  1. The University of Tokyo, Department of Chemistry, Hongo, Bunkyo-ku, Tokyo, Japan

Publication History

  1. Published Online: 22 OCT 2012

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Abstract

Iron has received much attention in recent years as a catalyst for cross-coupling reactions. Besides attractive features such as wide availability, low cost, and negligible toxicity, iron shows a unique reactivity that allows cross-couplings to proceed under mild reaction conditions with high chemoselectivity. Reactions of various nucleophiles (organomagnesium, -zinc, -copper, -boron, etc.) with alkenyl, aryl, alkyl, and miscellaneous electrophiles are described. Oxidative and reductive couplings and reactions involving C[BOND]H bond cleavage are also discussed. Several mechanistic possibilities and synthetic applications are briefly presented.

Keywords:

  • iron;
  • cross-coupling;
  • catalysis;
  • organometallic reagents;
  • chemoselectivity