Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part A. Antioxidant Compounds
Organic Selenium and Tellurium (2013)
Published Online: 17 JUN 2013
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
Patai's Chemistry of Functional Groups
How to Cite
L. Braga, A. and Rafique, J. 2013. Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part A. Antioxidant Compounds. Patai's Chemistry of Functional Groups. .
- Published Online: 17 JUN 2013
The design and synthesis of organoselenium compound as bioactive structures have achieved a new dimension since the 1970s, when many reports described the identification of various selenoproteins, which are involved in a wide variety of biological processes, including antioxidant defense, thyroid hormone production and immune response. In this chapter, strategies and methods for the preparation of synthetic antioxidants containing selenium are reviewed. The unique redox properties of selenium confer catalytic activity to organoselenium compounds and influence their biological properties as well as the methods selected for their preparation. Several approaches can be applied in order to obtain organoselenium compounds, such as reaction of elemental selenium or diselenides with different types of carbanions or reaction of organic electrophiles with selenolate anions generated by different methods, as discussed herein.
- lipid peroxidation;