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Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part B. Anti-infective and Anticancer Compounds

Organic Selenium and Tellurium (2013)

  1. Antonio L. Braga,
  2. Jamal Rafique

Published Online: 28 APR 2014

DOI: 10.1002/9780470682531.pat0728

Patai's Chemistry of Functional Groups

Patai's Chemistry of Functional Groups

How to Cite

Braga, A. L. and Rafique, J. 2014. Synthesis of Biologically Relevant Small Molecules Containing Selenium. Part B. Anti-infective and Anticancer Compounds. Patai's Chemistry of Functional Groups. 1–66.

Author Information

  1. LabSelen—Laboratório de Síntese de Pequenas Moléculas Quirais de Selênio e Telúrio, Dpto de Química—CFM, UFSC—Florianópolis, SC—Brazil

Publication History

  1. Published Online: 28 APR 2014

Abstract

In the 19705 many reports described the identification of various selenoproteins, which are involved in a wide variety of biological processes, including antioxidant defense, thyroid hormone production and immune response. This brought a new dimension to the design and synthesis of organoselenium compounds as bioactive structures. In this chapter, strategies and methods for the preparation of anti-infective, chemopreventive as well as anticancer compounds are reviewed. The unique redox properties of selenium confer catalytic activity to organoselenium compounds and influence their biological propert ies as well as the methods selected for their preparation. Several approaches can be applied In order to obtain organoselenium compounds, such as reaction of elemental selenium or diselenides with different types of carbon nucleophiles or reaction of organic electrophiles with selenolate anions generated by different methods, as discussed herein.

Keywords:

  • selenium;
  • diselenide;
  • antibacterial;
  • antifungal;
  • antiviral;
  • chemopreventive agents;
  • anticancer agents