Gold-Catalyzed Addition of HX to Alkynes
Organogold Compounds (2014)
Published Online: 22 JUN 2014
Copyright © 2009 John Wiley & Sons, Ltd. All rights reserved.
Patai's Chemistry of Functional Groups
How to Cite
Genin, E. and Michelet, V. 2014. Gold-Catalyzed Addition of HX to Alkynes. Patai's Chemistry of Functional Groups. 1–60.
- Published Online: 22 JUN 2014
Among the myriad of organic transformations that have been developed in the area of gold catalysis, the addition of HX to alkynes has been a field of intense investigation. This chapter presents the main and recent contributions in the field of gold-catalyzed nucleophilic addition of HX to alkynes. The presentation includes the addition of O-nucleophiles (including water, alcohols and carboxylic acids), of N-nucleophiles and other heteroatom nucleophiles (including thiols and halogens) to alkynes. The historical background for inter- and intramolecular additions, the domino processes and the applications to natural products synthesis are highlighted.
- carboxylic acid;
- nucleophilic addition;