Chapter 19. Treatment of Diabetic Neuropathy

  1. William H. Herman4,
  2. Ann Louise Kinmonth5,
  3. Nicholas J. Wareham6 and
  4. Rhys Williams7
  1. Rodica Pop-Busui1,
  2. Zachary Simmons2 and
  3. Eva L. Feldman3

Published Online: 12 JAN 2010

DOI: 10.1002/9780470682807.ch19

The Evidence Base for Diabetes Care, Second Edition

The Evidence Base for Diabetes Care, Second Edition

How to Cite

Pop-Busui, R., Simmons, Z. and Feldman, E. L. (2010) Treatment of Diabetic Neuropathy, in The Evidence Base for Diabetes Care, Second Edition (eds W. H. Herman, A. L. Kinmonth, N. J. Wareham and R. Williams), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470682807.ch19

Editor Information

  1. 4

    Department of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI, USA

  2. 5

    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

  3. 6

    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

  4. 7

    School of Medicine, Swansea University, Swansea, UK

Author Information

  1. 1

    Department of Internal Medicine, Division of Metabolism, Endocrinology, and Diabetes, University of Michigan Medical Center, Ann Arbor, MI, USA

  2. 2

    Pennsylvania State University College of Medicine, Hershey, PA, USA

  3. 3

    University of Michigan, Ann Arbor, MI, USA

Publication History

  1. Published Online: 12 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780470032749

Online ISBN: 9780470682807



  • diabetic neuropathy treatment;
  • diabetic neuropathy (DN) - demonstrable disorder, clinically evident or subclinical;
  • diabetic neuropathy prevalence;
  • Diabetes Control and Complication Trial (DCCT);
  • small-fibre polyneuropathy;
  • distal symmetric sensorimotor polyneuropathy;
  • Michigan Diabetes Neuropathy Scale (MDNS);
  • acute painful neuropathy - variant of DN with distinct mode of onset, signs and prognosis;
  • Quantitative sensory testing (QST) - measure assessing loss of protective sensation;
  • transcutaneous electrical nerve stimulation (TENS) and acupuncture


This chapter contains sections titled:

  • Definition

  • Prevalence of diabetic neuropathy

  • Pathogenesis

  • Classification of DN

  • Treatment

  • Autonomic neuropathy

  • Treatment

  • Conclusion

  • Acknowledgements

  • References