Chapter 4. Prevention of Type 1 Diabetes

  1. William H. Herman2,
  2. Ann Louise Kinmonth3,
  3. Nicholas J. Wareham4 and
  4. Rhys Williams5
  1. Jay S. Skyler

Published Online: 12 JAN 2010

DOI: 10.1002/9780470682807.ch4

The Evidence Base for Diabetes Care, Second Edition

The Evidence Base for Diabetes Care, Second Edition

How to Cite

Skyler, J. S. (2010) Prevention of Type 1 Diabetes, in The Evidence Base for Diabetes Care, Second Edition (eds W. H. Herman, A. L. Kinmonth, N. J. Wareham and R. Williams), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470682807.ch4

Editor Information

  1. 2

    Department of Internal Medicine and Epidemiology, University of Michigan, Ann Arbor, MI, USA

  2. 3

    General Practice and Primary Care Research Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK

  3. 4

    MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK

  4. 5

    School of Medicine, Swansea University, Swansea, UK

Author Information

  1. Division of Endocrinology, Diabetes and Metabolism, University of Miami, Miami, FL, USA

Publication History

  1. Published Online: 12 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780470032749

Online ISBN: 9780470682807



  • primary and primordial prevention and early detection;
  • prevention of type 1 diabetes;
  • type 1 diabetes - immune-mediated pancreatic islet β-cell destruction, absolute insulin deficiency;
  • interventions interdicting type 1 diabetes disease process;
  • impairment of β - cell function and loss of first-phase insulin response (FPIR) during intravenous glucose tolerance test (IVGTT);
  • individuals at type 1 diabetes risk and disease development prediction;
  • circulating autoantibodies to islet cell markers - detection type 1 diabetes diagnosis;
  • type 1 diabetes and progressive metabolic defect;
  • interruption of type 1 diabetes disease process;
  • TrialNet Oral Insulin Trial and TRIGR study - providing Level I Evidence


This chapter contains sections titled:

  • Risk identification

  • Interruption of the type 1 diabetes disease process

  • Studies in newly diagnosed diabetes

  • Studies in individuals at high risk of type 1 diabetes

  • Conclusion

  • References