Chapter 3. Neurobiological Substrates of CNS Disorders

  1. John Kelly

Published Online: 13 NOV 2009

DOI: 10.1002/9780470682920.ch3

Principles of CNS Drug Development: From Test Tube to Patient

Principles of CNS Drug Development: From Test Tube to Patient

How to Cite

Kelly, J. (2010) Neurobiological Substrates of CNS Disorders, in Principles of CNS Drug Development: From Test Tube to Patient, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470682920.ch3

Author Information

  1. Department of Pharmacology and Therapeutics, National University of Ireland, Galway, Ireland

Publication History

  1. Published Online: 13 NOV 2009
  2. Published Print: 8 JAN 2010

ISBN Information

Print ISBN: 9780470519790

Online ISBN: 9780470682920

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Keywords:

  • neurobiological substrates of CNS disorders;
  • chemical neurotransmission principles;
  • stages of chemical neurotransmission;
  • classification systems based on symptoms, and quantitative biological measures;
  • chemical neurotransmission - information transferred from one nerve cell to another via synapse;
  • approaches to investigating CNS alterations in CNS disorders;
  • neurobiological rationale for CNS disorders;
  • brain imaging - structural and/or functional alterations associated with CNS disorder symptoms;
  • finding neurobiological substrates of CNS disorders

Summary

This chapter contains sections titled:

  • Introduction

  • Brief introduction to the principles of chemical neurotransmission

  • Stages of chemical neurotransmission

  • Approaches to investigating CNS alterations in CNS disorders

  • Evidence for a neurobiological rationale for CNS disorders

  • Concluding comments

  • References