11. Design of Method Comparison Studies

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch11

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Design of Method Comparison Studies, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch11

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019

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Keywords:

  • mean parameter;
  • method comparison;
  • variance parameter

Summary

There are two sets of parameters of interest in a method comparison study: the mean parameters, governing the relationship between the means of measurements; and the variance parameters, describing the uncertainty within and between the methods. A common design is one where repeated measures are taken on the same persons. When we have a time dimension to the replicates it is recommended to include a random item replicate effect and, to the extent that we are interested in time trajectories, to include a systematic time effect in the model.

Controlled Vocabulary Terms

mean; variance