Chapter 11. Design of Method Comparison Studies

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch11

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Design of Method Comparison Studies, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch11

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019

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Keywords:

  • design of method comparison studies;
  • designing studies of method comparisons - items to analyze and experimental designs;
  • method comparison study, mean and variance parameters;
  • repeated measures designs - repeated measures taken on the same persons;
  • blood samples, at different times - during experiments;
  • time dimension to replicates - recommendation to include random item×replicate effect;
  • 50 items with three replicate measurements by each method - reasonable precision for parameters of interest;
  • mean parameters, precision of mean conversion equations between methods;
  • study design limiting factors and variance component estimation

Summary

This chapter contains sections titled:

  • Sample size

  • Repeated measures designs

  • Summary