2. Method Comparisons

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch2

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Method Comparisons, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch2

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019



  • correlation;
  • method comparison


When the same clinical or biochemical quantity can be measured in two ways, the natural question is to ask which one is better. This is not necessarily a meaningful question to ask, certainly not without further qualification. In this chapter the main problems and themes of method comparison are presented through three examples. There are, roughly speaking, two methods of measuring blood glucose: the cheap and easy method, based on a capillary blood sample taken from a simple finger prick and analyzed on a small desktop machine; and a more elaborate method, based on a venous blood sample analyzed in a proper clinical laboratory. When measurements are taken by two methods on a group of items, then the variation between items will introduce a strong correlation between the two sets of measurements.

Controlled Vocabulary Terms