5. Replicate Measurements

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch5

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Replicate Measurements, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch5

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019

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Keywords:

  • exchangeable replicates;
  • linked replicates;
  • replicate measurements

Summary

Replicate measurements come in two substantially different forms, depending on the circumstances under which they are taken: exchangeable and linked. Replicate measurements by a method on a given item are said to be exchangeable if there is no relationship between the first, second, etc. replicate across methods. When replicate measurements are available, the aim of the analysis is exactly the same as without replicates; derivation of a prediction interval for one method given the other, or, equivalently, derivation of a prediction interval for the difference. There are two basic ways of indicating in the plot how the replicates belong together within items, depending on whether replicates are linked or not.

Controlled Vocabulary Terms

replication