6. Several Methods of Measurement

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch6

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Several Methods of Measurement, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch6

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019



  • method comparisons;
  • replicate measurements;
  • residual variation


The model the author sets up for method comparisons with replicate measurements is generalizable to several methods of measurement. The joint model for three or more methods gives the same mean differences between pairs of methods as a person would get by using only the data from each pair of methods; they are merely the differences of the means of each method, except for special (uncommon) cases where some items lack measurements on one method. In the case of replicate measurements, it is possible to separate the residual variation and the method×item variation, and, if more than two methods are compared, to allow the latter to have method-specific variance too. It is of course still necessary to estimate an item×replicate variance if replicates are linked across methods.

Controlled Vocabulary Terms

measurement error; residual variation