9. Repeatability, Reproducibility and Coefficient of Variation

  1. Bendix Carstensen1,2

Published Online: 24 JUN 2010

DOI: 10.1002/9780470683019.ch9

Comparing Clinical Measurement Methods: A Practical Guide

Comparing Clinical Measurement Methods: A Practical Guide

How to Cite

Carstensen, B. (2010) Repeatability, Reproducibility and Coefficient of Variation, in Comparing Clinical Measurement Methods: A Practical Guide, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470683019.ch9

Author Information

  1. 1

    Steno Diabetes Center, Gentofte, Denmark

  2. 2

    Department of Biostatistics, University of Copenhagen, Denmark

Publication History

  1. Published Online: 24 JUN 2010
  2. Published Print: 13 AUG 2010

ISBN Information

Print ISBN: 9780470694237

Online ISBN: 9780470683019

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Keywords:

  • coefficient of variation;
  • measurement error;
  • repeatability;
  • reproducibility;
  • residual variation

Summary

Repeatability and reproducibility can only be assessed when replicate measurements by each method are available. If replicate measurements by a method are available, it is simple to estimate the measurement error for a method, using a model with fixed effect of item, and then taking the residual standard deviation as the measurement error standard deviation. The precision of a measurement method is often given as the coefficient of variation (CV). The variation used to estimate the CV based on log-transformed data is the residual variation derived using some model for the mean value. Occasionally, the overall residual standard deviation is just divided by the overall mean and used as estimate of the CV.

Controlled Vocabulary Terms

coefficient of variation; measurement error; residual variation