Chapter 13. Two-Stage Clonal Growth Modeling of Cancer

  1. Dr. Kannan Krishnan PhD, DABT, FATS Professor Director visiting scientist2 and
  2. Dr Melvin E. Andersen PhD, DABT, CIH, FATS Director3
  1. Rory B. Conolly1 and
  2. Dr Melvin E. Andersen PhD, DABT, CIH, FATS Director3

Published Online: 30 MAR 2010

DOI: 10.1002/9780470686263.ch13

Quantitative Modeling in Toxicology

Quantitative Modeling in Toxicology

How to Cite

Conolly, R. B. and Andersen, M. E. (2010) Two-Stage Clonal Growth Modeling of Cancer, in Quantitative Modeling in Toxicology (eds K. Krishnan and M. E. Andersen), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470686263.ch13

Editor Information

  1. 2

    Département de santé environnementale et santé au travail, Ecole de santé publique & Faculté de médecine, Université de Montréal, Montréal, Canada

  2. 3

    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA

Author Information

  1. 1

    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC, USA

  2. 3

    Program in Chemical Safety Sciences, The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA

  1. This manuscript has been reviewed by the National Center for Computational Toxicology, US Environmental Protection Agency and approved for publication. Approval dose not signify that the contents necessarily reflect the views and policies of the agency nor does the mention of trade names or commercial products constitute endorsement or recommendation for use.

Publication History

  1. Published Online: 30 MAR 2010
  2. Published Print: 26 MAR 2010

ISBN Information

Print ISBN: 9780470998090

Online ISBN: 9780470686263

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Keywords:

  • two-stage clonal growth modeling of cancer;
  • chemical toxicity and carcinogenicity testing - high visibility scientific and political concerns of the 70s;
  • two-stage clonal growth model (TSCGM) of cancer - three types, normal, intermediate and malignant cells;
  • two-stage clonal growth model for carcinogenesis;
  • modeling multiple modes of action for carcinogens;
  • model for cytotoxicity - and influence on tumor probability using Hoogenveen correction;
  • TSCGM model formulation - response evaluation for compounds with different modes of carcinogenicity;
  • receptor-mediated cell proliferation;
  • U-shaped tumor dose-response;
  • TSCGM simulations - for two modes of action with varying potency values

Summary

This chapter contains sections titled:

  • Introduction

  • Equations for the Two-Stage Clonal Growth Model

  • Modeling Multiple Modes of Action for Carcinogens

  • Conclusion

  • References