Chapter 6. Proteomics and Metabolomics for Biomarker Discovery: An Introduction to Spectral Data Analysis

  1. Dr Francisco Azuaje Senior Member Associate Editor

Published Online: 14 JAN 2010

DOI: 10.1002/9780470686423.ch6

Bioinformatics and Biomarker Discovery: “Omic” Data Analysis for Personalized Medicine

Bioinformatics and Biomarker Discovery: “Omic” Data Analysis for Personalized Medicine

How to Cite

Azuaje, F. (2010) Proteomics and Metabolomics for Biomarker Discovery: An Introduction to Spectral Data Analysis, in Bioinformatics and Biomarker Discovery: “Omic” Data Analysis for Personalized Medicine, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470686423.ch6

Author Information

  1. Public Research Centre for Health (CRP-Santé), Luxembourg

Publication History

  1. Published Online: 14 JAN 2010
  2. Published Print: 19 FEB 2010

ISBN Information

Print ISBN: 9780470744604

Online ISBN: 9780470686423

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Keywords:

  • translational bioinformatics;
  • biomarkers;
  • proteomics;
  • metabolomics;
  • metabonomics

Summary

This chapter offers an introduction to proteomics and metabolomics in the context of biomarker discovery. Basic concepts, techniques and recent applications are provided. Data types, technological platforms and analysis requirements in these areas are discussed. This involves reviews of techniques relevant to different types of spectral data analysis. Targeted and global analysis approaches to proteomics and metabolomics are introduced. The chapter further discusses problems, techniques and applications for feature transformation, selection and classification in the domain of spectral data mining. Key software and information resources for supporting proteomic and metabolomic research are reviewed. The chapter ends with a discussion on important gaps, challenges and emerging research directions for bioinformatics