Chapter 8. Oocyte-Specific Translational Control Mechanisms
- Marie-Hélène Verlhac2,
- Anne Villeneuve3
Published Online: 21 APR 2010
DOI: 10.1002/9780470687970.ch8
Copyright © 2010 John Wiley & Sons, Ltd
Book Title
Oogenesis: The Universal Process
Additional Information
How to Cite
Novoa, I., Eliscovich, C., Belloc, E. and Méndez, R. (2010) Oocyte-Specific Translational Control Mechanisms, in Oogenesis: The Universal Process (eds M.-H. Verlhac and A. Villeneuve), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9780470687970.ch8
Editor Information
- 2
Biologie du Développement – UMR 7622, UPMC-CNRS, 9 Quai St Bernard, 75252 Paris CEDEX 05, France
- 3
Department of Developmental Biology, Stanford University School of Medicine, Beckman Center, B300, 279 Campus Drive, Stanford, CA 94305-5329, USA
Publication History
- Published Online: 21 APR 2010
- Published Print: 12 MAR 2010
ISBN Information
Print ISBN: 9780470696828
Online ISBN: 9780470687970
- Summary
- Chapter
- References
Keywords:
- Cytoplasmic-Polyadenylation;
- deadenylation;
- translational regulation;
- RNA-binding proteis;
- 3'UTR;
- cap-binding protein;
- mRNA-localization;
- CPEB;
- C3H-4 meiosis;
- translational-feedback loop
Summary
During the growth period of oogenesis, meiotically-arrested oocytes accumulate large quantities of dormant mRNAs. Meiotic resumption is fully dependent on translation-regulation cascades of these maternal mRNAs. Not only the time of protein synthesis is finely regulated during this period, but the basic embryonic axis and the establishment of germ cells are also defined, through the localization of dormant mRNAs within the oocyte. The coordinated temporal and spatial regulation of the transcripts required to complete the two meiotic divisions, segregate correctly the chromosomes and establish the polarity in the egg, is orchestrated by RNA-binding proteins that recognize specific cis-acting elements in the 3'UTRs of groups of mRNAs implicated in similar functions. These RNA-binding proteins are organized in combinatorial networks stabilized by feedback loops that ensure unidirectional progression through meiosis to produce a functional egg.