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Phagocytes Part 1: Macrophages

Immunology

Innate Immunity and Infection

  1. Gordon D. Brown PhD1,
  2. Siamon Gordon MB ChB FAMS PhD2

Published Online: 15 MAR 2010

DOI: 10.1002/9780470688618.taw0084

Topley and Wilson's Microbiology and Microbial Infections

Topley and Wilson's Microbiology and Microbial Infections

How to Cite

Brown, G. D. and Gordon, S. 2010. Phagocytes Part 1: Macrophages. Topley and Wilson's Microbiology and Microbial Infections. .

Author Information

  1. 1

    University of Cape Town, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, CLS, Cape Town, South Africa

  2. 2

    University of Oxford, Glaxo Wellcome Professor of Cellular Pathology, Sir William Dunn School of Pathology, Oxford, UK

Publication History

  1. Published Online: 15 MAR 2010

Abstract

  • 1
    Origins of Macrophages
  • 2
    Recognition of Pathogens
  • 3
    Ingestion of Microbes
  • 4
    Antimicrobial Mechanisms
  • 5
    Macrophage Activation
  • 6
    Secretion of Soluble Mediators and Other Factors
  • 7
    Antigen Presentation
  • 8
    Subversion of Macrophage Function by Pathogens
  • 9
    Role of Macrophages in Homeostasis
  • 10
    Macrophage-Induced Pathology
  • 11
    Conclusion
  • 12
    Acknowledgments

Keywords:

  • phagocytes part 1-macrophages;
  • pathogen recognition;
  • macrophage activation;
  • secretion of soluble mediators and other factors;
  • antigen presentation;
  • subversion of macrophage function by pathogens;
  • macrophage role in homeostasis;
  • macrophage-induced pathology